![]() ![]() Glial activation in the spinal cord was quantified by immunohistochemical staining using GFAP (for astrocytes) and Iba-1 (for microglia) antibodies. Buja (300 mg/kg) was orally administrated for five consecutive days after the oxaliplatin injection. MethodsĬold and mechanical allodynia induced by an oxaliplatin injection (6 mg/kg, i.p.) in Sprauge-Dawley rats were evaluated by a tail immersion test in cold water (4 ☌) and a von Frey hair test, respectively. However, it remains to be elucidated whether and how Buja (Aconiti Tuber), a major ingredient of GBT, is involved in the efficacy of GBT. ![]() Our previous study demonstrated that Gyejigachulbu-Tang (GBT), a herbal complex formula, alleviates oxaliplatin-induced neuropathic pain in rats by suppressing spinal glial activation. IL-1β and TNF-α) in the spinal cord play a crucial role in the pathogenesis of neuropathic pain. astrocytes and microglia) and increase of pro-inflammatory cytokines (e.g. Oxaliplatin, a widely used anticancer drug against metastatic colorectal cancer, can induce acute peripheral neuropathy, which is characterized by cold and mechanical allodynia.
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